"Acellular vaccines can provide good early immunity with less risk of side effects, but the immune responses they induce wane with time." "Whole-cell vaccines elicit a broad range of immune responses, often just as an infection would, but can cause side effects and are hard to standardize," said Malley. Both categories have advantages and disadvantages. This new approach permits rapid construction of new vaccines that activate multiple arms of the immune system simultaneously against one or more pathogens, generating robust immune protection with a lower risk of adverse effects.Īs reported in the Proceedings of the National Academy of Science on July 29, by Ying-Jie Lu, HMS assistant professor of pediatrics at Boston Children’s Hospital and Richard Malley, HMS associate professor of pediatrics at Boston Children's Hospital Division of Infectious Disease, and Fan Zhang, an HMS research fellow in pediatrics, the method could speed development of new vaccines for a range of globally dangerous pathogens, or infectious agents.īroadly speaking, currently available vaccines fall into two categories: whole-cell vaccines, which rely on weakened or dead bacteria or viruses and acellular or subunit vaccines, which include a limited number of antigens-portions of a pathogen that trigger an immune response. Researchers at Boston Children's Hospital have developed a new method of vaccine design called the Multiple Antigen Presentation System (MAPS). Harvard COVID-19 Information: Keep Harvard Healthy. ![]() Research Departments, Centers, Initiatives and more.
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